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IgG can induce pain independent of overt inflammation or nerve damage, and a role for antibodies has been identified in other nociplastic pain conditions like complex regional pain syndrome

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Lab Invest 99:749763 Zidan A, Hedya SE, Elfeky DM, Abdin AA (2018) The possible anti-apoptotic and antioxidant effects of acetyl l-carnitine as an add-on therapy on a relapsing-remitting model of experimental autoimmune encephalomyelitis in rats