Specific situations requiring medical review include: Severe or persistent gastrointestinal side effects from Mounjaro that significantly limit your food intake for more than a few days You are taking metformin in addition to Mounjaro, as this combination increases B12 deficiency risk You have a history of pernicious anaemia, gastric surgery, or conditions affecting nutrient absorption You are considering stopping B12 injections whilst taking Mounjaro You experience any unexplained neurological symptoms Urgent medical attention is needed if you develop severe, persistent abdominal pain (which may radiate to the back), persistent vomiting, fever, or yellowing of the skin/eyes, as these could indicate pancreatitis or gallbladder problems Your GP or practice nurse can arrange blood tests to check your B12 levels (serum B12, holotranscobalamin, and if borderline, methylmalonic acid levels may be used where available) and determine the appropriate frequency of B12 injections if deficiency is confirmed

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Store reconstituted solutions in sealed containers under inert gas if extended storage is required
Illness and conditions linked to B12 deficiency: Neuropsychiatric disorders - The earliest symptoms of B12 deficiency include: Irritability Mood swings Confusion Forgetfulness Fogginess Psychosis Hallucinations or delusion Depression Anxiety/Panic attacks Tension headaches Onset of dementia Neurological disorders Bells Palsy Chronic Fatigue Syndrome (CFS) Myalgic Encephalomyelitis (ME) Autoimmune Disorders - Autoimmune disorders take many forms
These include: Eggs Fish Meat Dairy products Some fortified foods Vitamin B12 is a water-soluble vitamin that helps with red blood cell and nerve cell formation, as well as DNA production
Do not use the medication