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Semaglutide activates GLP-1 receptors in the brain and gut

In a Phase II trial of patients with metastatic pancreatic ductal adenocarcinoma (PDA) refractory to prior therapy, combination therapy with oral Entinostat (5 mg weekly) and intravenous Nivolumab (240 mg every 2 weeks) yielded partial responses in 11.1% (3/27) of patients, with response durations reaching 10.2 months

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