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Cytochrome 2E1 (CYP2E1) is the primary enzyme responsible for the conversion of acetaminophen to its toxic metabolite

Many patients, particularly those over 50 or those with chronic stress, medication side effects, or hormonal changes, have both components affected simultaneously, and the physician may prescribe both approaches in coordination

Those who don't often experience mood destabilisation they attribute to the wrong cause

Before starting Cymbalta, talk to your doctor about any medications you are currently on to minimize your risk of side effects