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Next-generation injectables : Lilly's retatrutide , a triple hormone receptor agonist targeting GLP-1, GIP, and glucagon pathways simultaneously, reported Phase 3 results in May 2026 showing 28.3% weight loss on the highest 12 mg dose at 80 weeks the largest weight loss from any approved or investigational drug in this class to date
According to FDA labeling, GLP-1 medications should be discontinued immediately and not restarted if pancreatitis is confirmed
If someone wants to come off medicine, its okay to accept some weight gain if metabolic biomarkers stay in an improved state. Aside from people who want to quit taking GLP-1 medications, there are also those who are forced to stop
However, germs are still everywhere
Endocrine Practice
21 (2), e07869
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