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Starting dose is typically 5 mg three times daily, titrated according to response

Currently, the FDA-approved weight management indication requires a BMI of at least 27 with comorbidities

It also slows the emptying of the stomach, enhancing the sensation of fullness after meals

Most aesthetic providers recommend waiting until weight has been stable for at least several months before pursuing filler or other volume-restoring treatments

Average weight loss during this time could be around 5% of total body weight

Some preliminary research suggests berberine may influence incretin secretion indirectly, but this does not make it a GLP-1 agonist in the pharmacological sense