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The study is described as a first-of-its-kind global clinical trial designed to evaluate whether combining a proven multidomain lifestyle intervention with a metabolism-targeting drug, such as a GLP-1 agonist, can further reduce the risk of cognitive decline, mild cognitive impairment (MCI), and dementia in at-risk older adults

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New weight loss pill offers needle-free option as demand for GLP-1 drugs surges A new option is now available for millions of Americans looking to lose weight without the need for injections

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) were introduced into clinical practice in 2005 for the treatment of type 2 diabetes mellitus (T2DM)

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This could be particularly important for women whose estradiol levels are abnormal, perhaps as a result of ovarian dysfunction, or whose estradiol levels drop, as part of the normal estradiol decline during menopause