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Their research has influenced international AIDS programs and is considered to have played a pivotal role in enhancing the infectious disease response capabilities of South Africa in particular.

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SLC7A11 is an essential components of the glutathione (GSH)-glutathione peroxidase 4 (GPX4) antioxidant systems that prevents ferroptosis, while ALOX5 is a member of the lipoxygenase family that is closely related to lipid peroxidation and induction of ferroptosis 10,33

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