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For example, individuals with loss-of-function mutations of the DPP1 gene develop prepubertal aggressive periodontitis, Papillon-Lefvre syndrome (PLS) ( In this review, we provide an overview of DPP1, its functional biochemical properties, the consequences of its inactivation and deficiency, and NSP pathophysiology in a variety of disorders

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SAM is a methyl group donor for the methylation of DNA and proteins [257]