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Like other members of the family, it prefers proline or alanine in the penultimate position, although peptides with other residues (glycine, serine, valine) in this position can be cleaved, albeit more slowly (Figure 1)

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(2008) 22(Suppl 2):S1421

In addition, -syn and p--syn levels increased in the insoluble fraction of RIPA following hypoxic treatment for 7 days, suggesting that hypoxia promoted the phosphorylation of -syn and long-term hypoxia promoted -syn to form abnormal aggregates in the insoluble fraction (Fig