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Oxidative stress has been demonstrated to enhance the activity of protein arginine N-methyltransferase (PRMT) and reduce the activity of dimethylarginine dimethylaminohydrolase (DDAH), an ADMA-degrading enzyme, thus resulting in a rise in ADMA concentrations [69, 151, 152]
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Many people report stronger sensations during infusion at this level, which is why slower administration and clinician supervision are essential
These alterations in synaptic activity provide insights into the regional vulnerabilities contributing to NPS in AD
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