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Glutathione is found in virtually every cell of the body and plays a critical role in protein synthesis, enzyme function, transport, and cell maturation*

112 When GSH is oxidized, it forms GSH disulphide, which can be reduced again to GSH with the help of glutathione reductases, another Nrf2 targets, in an NADPH-dependent manner

Matharu RK, Tabish TA, Trakoolwilaiwan T, Mansfield J, Moger J, Wu T, et al

Dietary phosphate restriction attenuates polycystic kidney disease in mice

In summary, microbial dysbiosis contributes to the onset and progression of LN by disrupting the intestinal barrier integrity and promoting systemic immune activation