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For Zepbound (weight management indication), doses increase from 2.5 mg to 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg at 4-week intervals as tolerated

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basal insulin cut from 47 to 8-20 IU replacing basal-bolus (SURPASS-6)

Notably, in the context of anti-tumor therapy, GLUT3 is highly expressed in highly aggressive tumors, particularly brain tumors, making it a promising therapeutic target for glioblastoma and brain metastases

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Unreconstituted lyophilized peptide powder is more temperature-stable but once mixed with bacteriostatic water, consistent refrigeration is required to prevent protein degradation