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Glutamate toxicity can be reduced by antioxidants, and the psychoactive principle of cannabis, tetrahydrocannabinol (THC), and the non-psychoactive principle cannabidiol (CBD), and other cannabinoids, is found to block glutamate neurotoxicity with a similar potency, and thereby potent antioxidants

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However, knockdown of neither GPX4 nor TAK1 combined with GPX4 overexpression had a significant effect on the MAPK-p38 pathway, which suggests that the two branches of MAPK may be regulated differently in EBV-positive NPC cells

PPAR Res

We further validated the ubiquitination of PPAR by NEDD4

Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation