What you lose is the temporary elevation in antioxidant capacity, which means oxidative stress markers return to pre-supplementation levels once circulating GSH drops
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That means GLP-1 receptor agonist users were more than twice as likely to develop allodynia compared to an active comparator group, not just compared to the general population
All approved injection sites (abdomen, thigh, and upper arm) provide appropriate absorption when used correctly
Additional studies in other models, including evaluations of administration and toxicity, will be needed to determine the broader applicability of xCT inhibition in this context