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The meta-analysis included 45 research articles

No matter how you look at it, they are an indication that something is changing in the body

They also slow gastric emptying , meaning food moves more slowly from the stomach into the intestines, which promotes satiety and reduces appetite

The results for orforglipron, an oral glucagon-like peptide-1 (GLP-1) receptor agonist, show less dramatic weight loss than injectable medications but are still clinically meaningful, according to the manufacturer Eli Lilly

However, the exact mechanism of these responses remains unclear

Therapeutic efforts aimed at neutralizing these pathological processes have thus far yielded limited results