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Turner RC, Cull CA, Frighi V, Holman RR

Zinc deficiency impairs neutrophil chemotaxis, as shown in models of crush syndrome where zinc chelation reduced neutrophil infiltration and muscle injury, indicating that adequate zinc levels are crucial for optimal neutrophil function migration [137]

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Fecal microbiota transplantation from patients with Parkinsons disease into germ-free mice has been shown to reproduce aspects of motor dysfunction and inflammatory responses, supporting an association between gut microbiota alterations and disease-related phenotypes [59]

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However, despite their effectiveness in rodent B cells, these agents do not induce the same proliferative response in human beta cells