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Infantile hypophosphatasia: transplantation therapy trial using bone fragments and cultured osteoblasts

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This process, coupled with an imbalanced reactive oxygen species (ROS) production that exceeds antioxidant capacity, culminates in cellular senescence ( Calcium crystals and breakdown products can trigger an inflammatory cascade in the articular cartilage and the synovial membrane by pattern recognition receptors (PRRs) of the innate response as a part of a sterile tissue injury ( in vitro [31, 32]

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I create a pulse-like response, replicating the bodys natural secretion rhythm, which may reduce risks linked with direct hormone injections