glp-1 and insulin resistance Agonist: The Good, the Bad the Ugly Dual and Triple Gut Peptide

Your body also tries to send out hunger signals and get you to eat more, and though GLP-1 medications do a great job of tuning those signals out, they have little effect on the overall metabolic slowdown

(Lond) 3 (1), 136

10.1124/jpet.107.128009 330 WorthleyM

The effects are really great, no side effects

If fatigue is a problem despite being on both therapies, check that you are eating enough total calories and protein

Importantly, unlike monotherapy with pure glucagon agonists, retatrutide did not cause worsening of glycemic control the concurrent GLP-1 and GIP activity effectively offset any hyperglycemic tendency from glucagon receptor activation