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Another clinical study investigated the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of pharmacological ascorbic acid when it is combined with mFOLFOX6 or FOLFIRI with or without bevacizumab regimens in patients with metastatic colorectal cancer or gastric cancer

Amini A, Hamann S, Larsen M

4e, f, both G/D-CuP and D-CuP exhibited a significant reduction in the expression levels of pro-inflammatory cytokines