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Although biopsies are not usually performed, pathological examination of HS lesions may reveal the presence of an infundibular lymphocytic infiltrate, follicular epidermal hyperplasia and hyperkeratosis, fistulous tracts, tunnels, cysts, follicular rupture and dermal fibrosis.4 Imaging tests, such as skin ultrasound and MRI, represent important additional tools to clinical examination, which are very useful to characterise the morphology and depth of lesions in a more accurate way, detect any subclinical disease, and improve therapeutic management in these patients.4,50 The main differential diagnoses of HS primarily include conditions of infectious aetiology (pyoderma folliculitis, boils, granuloma inguinale, lymphogranuloma venereum, actinomycosis, scrofuloderma), as well as perianal Crohn's disease.40 Treatment Treatment of HS is often challenging and should be individualised and patient-oriented, considering both medical and surgical treatment modalities

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