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Author contributions LF and Y-QH: study concept and design and drafting of the manuscript

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NAD+ declines with age and is an essential coenzyme for a number of enzymes involved with energy production and cellular repair

It is at the vanguard of prospective therapeutic treatments for treating metabolic diseases, obesity, and possibly even the cellular mechanisms involved in aging because of its ability to block the enzyme Nicotinamide N-methyltransferase (NNMT)

Injections bypass the gastrointestinal tract and are the standard treatment for pernicious anaemia and severe deficiency in the UK

The Vitamin B complex works together to support energy production, brain function, mood balance, and metabolic health