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By utilizing a 4-week cycle, researchers target this specific window of high metabolic demand

While the concept of post-inflammatory pigment deposition is biologically plausible in oral mucosa - the tissue does contain melanocytes capable of responding to inflammatory signals - the specific studies informing this article focus on other mechanisms: endocrine (Patil and Mitra 2026), medication-induced (Ajmera et al

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Laboratory investigations have reported measurable changes in nitric oxide related signaling markers, endothelial migration assays, fibroblast gene expression profiles, and cytoskeletal reorganization markers in cell culture and animal models

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