Treatment with A 40 oligomers significantly reduced the cell viability and apoptosis of astrocyte brain cultures and increased oxidative modifications of DNA, lipids, and protein, enhanced pro-inflammatory cytokine release and increased the activity of the proteolytic matrix metalloproteinase enzyme, matric metalloproteinase (MMP)-2 and reduced the activity of MMP-9 after 24 h
doi: 10.1016/S0140-6736(18)31132-2
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There is a high chance that missing information was due to informative censoring and in the absence of additional analyses evaluating the missing data patterns, it is not possible to draw firm conclusions on the results from the analyses on body weight at week 208
NICE guidelines (NG28) recommend blood pressure targets below 140/80 mmHg (or 130/80 mmHg if kidney, eye, or cerebrovascular damage is present) and lipid management according to cardiovascular risk
