It was well-known that ASD affected males more than females by a ratio of 4:1 ( ASD was considered as a heterogeneous disorder
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Concurrently, downregulation of STAMBP and NEP may impair protein clearance mechanisms, exacerbating proteotoxic stress and -amyloid (A) deposition [52], ultimately triggering neuronal apoptosis, which aligns with our previous observation of reduced MAP2-positive neurons
Crucially, the weight loss trajectory at 26 weeks had not plateaued suggesting that longer treatment duration would produce further reductions