glp 1 with kidney disease SGLT2 vs GLP-1 for CKD: Which Is Better? Frontiers | GLP-1 Receptor Agonists

Crespel, A., De Boisvilliers, F., Gros, L., Kervran, A

When a medication changes the pace of digestion, absorption can become part of the story

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Yet people looking to take a GLP-1 RA (or glucagon-like peptide 1 receptor agonist) dont have to see a specialist or even their primary care physician to get their hands on these drugs

The current medications vary in mechanism and magnitude: Semaglutide (Ozempic) targets GLP-1 receptors - around 15% average weight loss Tirzepatide (Mounjaro) targets GLP-1 + GIP - around 20% weight loss, often better GI tolerance Retatrutide (Phase 3 Trials) targets three receptors around 24% weight loss in trials, with broader metabolic effects The real risk is muscle mass loss

Ozempic, tirzepatide, and pregnancy Not directly