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Notably, GSH depletion and/or GPX4 downregulation have also been linked to pathological oxidative stress in vivo, such as ischemia/reperfusion cardiac injury and doxorubicin induced cardiomyopathy 41, 42

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Further modifications of mycobiome are associated with growth and developmental stages from infancy to adolescence and are driven by the advancement of the immune system-associated microbial community [25], intrinsic factors [genetics, sex, age], and extrinsic factors [food, medication, hygiene] [26]

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10.1186/1471-2164-14-362 [DOI] [PMC free article] [PubMed] Andersen ML, Ribeiro DA, Bergamaschi CT et al (2009) Distinct effects of acute and chronic sleep loss on DNA damage in rats