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Research in animal models has documented increased longitudinal bone growth in young subjects (PMID: 10373343) and increased bone mineral content (BMC) due to increased volume of bone, though bone mineral density itself remained unchanged (PMID: 10828840)

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Ito T, Kawahara K, Das A, Strudwick W

In terms of their structural composition, these agents can be divided into two main categories: modified versions of native GLP-1 that are resistant to DPP-4 and those that mimic Ex-4, activating GLP-1 R in a manner that is comparable to that of native GLP-1