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Tirzepatide (Zepbound/Mounjaro) at 15mg produces 20.9% over 72 weeks

Step 3: Preparation of compound of formula-2 THF (210 ml) was added to the compound obtained in step-2 at 25-30C

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The in vitro study showed that PEG2k-N-GLP-1 exhibited a significant reduction in potency, which is likely due to the steric hindrance of PEG shielding the GLP-1 receptor interaction [102]