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As the majority of patients with type 2 diabetes are overweight or obese this offers a potential advantage over older, established therapies, and DPP-4 inhibitors are being used in clinical practice as second-line therapy in addition to metformin in overweight and obese patients who fail to reach glycemic targets with metformin monotherapy

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Linda Bluestein: And I wanted to also circle back to when you mentioned PANS and PANDAS

Coordination between specialists may be beneficial, particularly if thyroid disease management is complex or if significant dose adjustments to levothyroxine are anticipated

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