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The primary endpoint, ACR20 response rate, was 80.8% in the metformin group versus 54.7% in the placebo group (P = 0.001)

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Dihydroxyacetone, the active browning ingredient in sunless tanning lotions, induces DNA damage, cell-cycle block and apoptosis in cultured HaCaT keratinocytes

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Laursen JB, Somers M, Kurz S, McCann L, Warnholtz A, Freeman BA, Tarpey M, Fukai T, Harrison DG

In the complex environment of the bile acid pool, different bile acid species serve as ligands with varying binding affinities and transcriptional activities for the same receptor