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Compared with the placebo group, the semaglutide group saw a net 8.1% decrease in UACR for patients with normal albumin levels at baseline, 27.2% for those with albuminuria category A2 (microalbuminuria) at baseline and 31.4% for those with albuminuria category A3 (macroalbuminuria) at baseline
Patients in both cohorts were predominantly female and accounted for 79.8% and 77.9% of those treated with semaglutide 2.4 mg and tirzepatide, respectively
Because GLP-1 drugs work partly by slowing gastric emptying which creates feelings of fullness there is a plausible biological mechanism
Its use is currently confined to clinical trials
J R Soc Interface (2016) 13
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