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Active Rac is then returned to the nearby plasma membrane by an Arf6-dependent recycling pathway to maintain localized actin polymerization in dorsal ruffles

Int J Gynecology Obstetrics

Copper is essential but toxic in excess, and the body tightly regulates it through plasma-protein binding and biliary excretion

10.1074/jbc.274.46.33148 345 YoshiokaK.OtaniH.ShimazuT.FujitaM.IwasakaT.ShiojimaI

Other mechanisms include increased insulin resistance induced by high-dose glucocorticoids that increases intra-portal insulin, decreases IGFBP-1 that increases free IGF-I, and direct glucocorticoid effects in increasing hepatic IGF-I synthesis and decreasing hepatic insulin clearance (105)