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In some embodiments, the otic formulation or composition comprises between about 0.01% to about 10% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

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[DOI] [PMC free article] [PubMed] [Google Scholar] 137.Triggiano F., Veschetti E., Veneri F., Montagna M.T., De Giglio O

Therefore, the core mechanism of hormonal imbalance in uterine fibroids lies in the dominant driving role of E 2 and the synergistic amplifying effect of progesterone