Additionally, downregulation of miR-155-5p decreased MDA content, increased the GSH/GSSG ratio, and elevated the protein expression levels of GPX4 and SLC7A11 in KGN cells (Figure 6), suggesting that miR-155-5p downregulation also reduces ferroptosis in KGN cells
Our data showed that (1) METH induced oxidative stress on brain tissues and decreased level of SH group, glutathione, enzymatic antioxidant activity and increased MDA levels, (2) brain oxidative enzymatic activity was enhanced and lipid peroxidation was alleviated by CoQ10
hdl:20.500.12749/1682
To determine the causal direction and assess the potential therapeutic value of regulating regulation in obesity-related metabolic diseases, further in-depth mechanistic and translational medicine research is needed to clarify the causal relationships and identify potential intervention targets within this endocrine-metabolic network
EBioMedicine 43 , 607619 (2019)
Creatine supplementation causes intracellular water retention in muscle tissue, which accounts for initial weight gain of 2-4 pounds