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Schooneman MG, Ten Have GAM, van Vlies N, Houten SM, Deutz NEP, Soeters MR

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Furthermore, in signaling studies that used cell lines with recombinantly expressed human GIPR or GLP-1R, tirzepatide stimulated cyclic adenosine monophosphate (cAMP) accumulation by either receptor with potency similar to that of native GIP and approximately 13-fold weaker than that of native GLP-1 [1]

10.1016/j.taap.2020.115131 204 XieY.ZhangD.ZhangJ.YuanJ