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That binding triggers a release of TNF- and other cytokines that cause local liver injury and spill into the general circulation, according to the research

Inflammation, steatosis, ballooning, and fibrosis are the features of non-alcoholic fatty liver disease (NAFLD), and the associated critical bona fide genes such as MCP-1, TNF, TNFR1, TGF1, Col1, SMA, Timp1, and Hp were significantly enriched in the livers of mice fed an HFD

These findings have important clinical ramifications with the possibility of targeting ferroptosis pathway in GPX4-overexpressing thyroid cancers