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Multiple cell types, including fibroblasts, endothelial cells, and keratinocytes, participate in wound repair by forming new tissues to fill defects, such as neovessels, ECM components, and granulation tissue, ultimately achieving epithelialization [27,28,29]

Craniomaxillofac Trauma Reconstr 2010;3:816

MOTS-c modulates the FOXO transcription factors and regulates cellular senescence, the state in which aged or damaged cells stop dividing but refuse to die, instead secreting a cocktail of inflammatory signals known as the senescence-associated secretory phenotype (SASP)

These mixed responses cannot be generalized, but the fact that a subset experience real improvement makes this an important signal to investigate

The peptide is also reported to remain stable in human gastric juice for over 24 hours, which is unusual and theorized to underpin oral activity in animals

It functions more like a hormone