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Data Coordinating CenterDouglas Curran-Everett*, Ruthie Knowles, Maura Robinson, and Lori Silveira

doi: 10.1210/jc.2019-00296 43

Do different PTM types (e.g., lactylation vs acetylation) exhibit competition or synergy under the same metabolite context

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Survodutide, as a dual GLP-1/glucagon receptor agonist, further supports the plausibility of glucagon receptor activation as a useful therapeutic component when paired with GLP-1 signaling

People who are otherwise healthy may be less willing to accept these potentially serious adverse events. GLP-1 agonists were originally developed for managing Type 2 diabetes, but exploded in popularity over the past decade as an off-label weight-loss tool, reaching approximately 40 million prescriptions in the U.S