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Olaparib is a compound that effectively inhibits PARP1 and PARP2, binding to the catalytic domain and preventing the transfer of ADP-ribose units from NAD + to target proteins, thus lowering NAD + consumption 160,161

To view a copy of this licence, visit About this article Cite this article Go, E.J., Hwang, SM., Jo, H

Consequently, Huang et al

As shown in Figure S7, key differences in the binding modes of non-cyclic ligand 7a and cyclic ligands 7b 7i were revealed through analysis of their intermolecular interaction profiles, with 7a forming numerous but low-frequency contacts - likely due to its flexible warhead - while the more rigid cyclic ligands engaged in fewer but higher-frequency interactions, indicating slightly greater binding specificity and complex stability

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doi: 10.1038/nature18646 96 PengQ.ChenX.LiangX.OuyangJ.WangQ.RenS.et al