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46 In patients with T2DM, the Tirzepatide versus Semaglutide once weekly in patients with T2DM (SURPASS-2) trial compared tirzepatide with semaglutide 1 mg (both as add-on therapies to metformin) and found tirzepatide was either noninferior or superior at all doses (5 mg, 10 mg 15 mg), for both HbA 1c reduction and weight loss at 40 weeks

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