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This transporter is localized on the apical membrane of enterocytes, as shown by immunofluorescence staining on Caco2 cells in a transwell system, and mediates Mn efflux into the lumen (Taylor et al., 2019)

The formation and activation of the PANoptosome within a single cell also support PANoptosis

Studies have also examined it in models involving neuropathic and metabolic stress responses

This is compensated in vivo by a simultaneous attack of a cocktail of components (defensins, cathelicidins) that disrupt the membrane integrity

Q., Wang, X

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