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NICE guidelines recommend multicomponent lifestyle interventions as the foundation for weight management, with pharmacological options like semaglutide reserved for specific patient groups meeting eligibility criteria

Per milliliter: Cyanocobalamin: 2,750 mcg, Hydroxocobalamin: 2,750 mcg, Vehicle, cbp: 1 ml

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after 4 weeks, increase to 5 mg injected subcutaneously once weekly

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For each participant and each clock, we computed the annualized rate of epigenetic age change by dividing the difference between the Week 32 and baseline epigenetic age estimates by the duration of follow-up expressed in years, yielding units of epigenetic years per calendar year