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In a randomized, double-blind, placebo-controlled trial in 2,919 participants (65 years) with elevated blood concentrations of homocysteine, supplementation with vitamin B 12 (500 g/day) and folic acid (400 g/day) for two years did not decrease the risk of osteoporotic fracture despite reductions in homocysteine (120, 121)

Because serum alanine aminotransferase (ALT) levels have been reported to predict the histological course of NASH and because strict control of ALT is required to prevent the progression of NASH [13], the primary outcome of this study was a change in ALT levels

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In Phase 2 clinical trials, retatrutide demonstrated substantial reductions in body weight

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