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After three months of intragastric Dihexa administration (1.44 or 2.88 mg/kg), the APP/PS1 mice showed restored Morris water maze performance, increased neuronal cell counts and synaptophysin expression on Nissl staining, reduced microglial and astrocyte activation, decreased pro-inflammatory cytokines (IL-1, TNF-) and increased anti-inflammatory IL-10

Patients typically notice improvements in energy, digestion, and body composition within 6 to 12 weeks, especially when combined with proper nutrition and exercise

2018 Aug 10;73(9):1258-1264

What we do not have: large-scale human RCTs

Understanding these differences helps optimize protocol selection for GERD specifically

Keep in mind that the best option depends on the underlying cause of the deficiency and your healthcare provider's recommendations