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Experimental studies have demonstrated that a copper-deficient diet exacerbates myocardial dysfunction in HF models [205]

Citation255 Thus, a key focus for the clinical development of these therapies will be determining optimal dosing regimens and ensuring the safe use of these agents without disrupting vital physiological processes

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C max was analysed using the same approach, whereas t max and all exploratory pharmacokinetic endpoints were summarised by renal function group using descriptive statistics

Facts and figuresresults of the 2006 AVMA survey of companion animal ownership in US pet-owning households