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4) randomized controlled trial

Micallef et al., 2020a

Ca 2+ overload can trigger the activation of multiple signaling pathways, such as the calcineurin/nuclear factor of activated T-cells pathway [88] and the cyclic adenosine monophosphate/protein kinase A pathway [89], in addition to exerting significant effects on mitochondrial function

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Tesamorelin + Ipamorelin is the only viable option

This narrow endocrine footprint makes it a cleaner pharmacological tool for research, allowing investigators to study GH-mediated effects without the confounding influence of simultaneously altered stress hormone or prolactin levels