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18 , 58 The uptake of copper by the liver varied according to the stage of diseasegreatest in early disease and after removal of excess copper by chelators, and less in advanced disease when the liver was loaded with copperbut in neither situation was there a peak of activity in the lower abdomen (representing excretion of copper in bile and thence into the intestine) as seen in normal individuals

AD: autosomal dominant, AR: autosomal recessive, EDS/OI: Ehlers-Danlos syndrome/osteogenesis imperfect, JHS: joint hypermobility syndrome, XLD: X-linked dominant

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Some people may recognize phentermine as an ingredient of the prescription drug Qsymia, a weight-loss medication that contains a combination of topiramate and phentermine

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Can we improve metabolic efficiency at a molecular level