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as a key regulator of mitochondrial biogenesis, PGC1 enhances mitochondrial function in myoblasts, supplies sufficient energy for differentiation, and regulates the transcription of myogenic genes to accelerate myotube maturation

it upregulates the expression of tight junction proteins (e.g., ZO-1 and occludin) in colon tissue, repairs the intestinal epithelial barrier, reduces serum FD4 (fluorescein isothiocyanatedextran) levels, decreases intestinal permeability, prevents bacterial and metabolite translocation, and lowers serum LPS levels