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Furthermore, the proportion of patients with improved fibrosis in the placebo group in the trial of Newsome et al [20] (33%) was higher than that reported in the LEAN trial (14%) or the pooled placebo outcomes of 23 RCTs involving patients with NAFLD (21%), possibly contributing to the non-significant treatment effect estimate[24,25]

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Carvedilol activates nuclear factor E2-related factor 2/antioxidant response element pathway to inhibit oxidative stress and apoptosis of retinal pigment epithelial cells induced by high glucose